PP405: Promising New Hair Loss Treatment Could Transform Care in India, Pending Trials

What Do David Beckham, Elon Musk, Sourav Ganguly, and Himesh Reshammiya Have in Common?

They all lost their hair at one point—and managed to grow it back.

No, it wasn’t magic. It was science.

Most of them reportedly turned to hair transplants, a solution that’s long, painful, and extremely expensive. But now, a new drug is making waves across the West, and it’s fuelling what some are calling the beginning of the “Great Unbalding.”

PP405 Hair Treatment

Enter PP405 — a new treatment that targets the root cause of most hair loss: DHT (dihydrotestosterone), a hormone notorious for shrinking hair follicles until they stop producing hair altogether.

What makes PP405 stand out is how it works — and who it could work for. It’s a topical treatment (no pills, no injections) that may benefit both men and women. Early buzz in dermatology circles suggests it could be a real game-changer.

“For a while now, dermatologists have been aware of the limitations of existing baldness treatments like minoxidil or finasteride,” says Dr. Sandip Agnihotri, Consultant Dermatologist. “PP405 works via an entirely new pathway — through lactate dehydrogenase — and seems to overcome those limitations. So far, it appears to be the safest, but we need to wait for post-market trials.”

What Makes PP405 Hair Treatment Solution Different?

Unlike most treatments that simply try to slow down hair loss, PP405 aims to reverse it. Here’s how:

PP405 Reactivates Dormant Follicles

PP405 blocks something called mitochondrial pyruvate carriers (MPCs)—essentially "off switches" in hair follicles. By shutting these down, the drug reawakens stem cells in dormant follicles and kickstarts new hair growth.

PP405 Works Faster Than Existing Treatments

Early trial results showed a 20%+ increase in hair density within 8 weeks — much quicker than standard therapies.

PP405 Hair Treatment Avoids Hormonal Side Effects

Since it’s applied topically and doesn’t interfere with hormones, PP405 avoids the sexual and systemic side effects linked to drugs like finasteride.

What Doctor Says about PP405? 

But before you get too excited — a word of caution.

“We’ve only seen phase two trials so far,” says Dr. Kiran Kaur Sethi, MD, medical director at Isya Aesthetics and bestselling author of *Skin Sense*. “Until phase 3 and 4 trials are completed, and we have more data on side effects and long-term results, PP405 won’t be available for public use. So we wait — with bated breath.”

The buzz around PP405 is real — and for good reason. If future trials confirm its safety and effectiveness, it could be a breakthrough treatment for androgenetic alopecia, more commonly known as pattern baldness.

And with the success of the weight loss drug revolution still fresh, the big question now is:

Is “unbalding” the next frontier?